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Both α 1 and α 2 adrenoceptors are localized within the hypothalamus (Young and Kuhar, 1980), and direct injections of prazosin into the hypothalamic paraventricular nucleus (PVN) can reverse the anorexic effect of a systemically administered α 1 adrenoceptor agonist (Wellman and Davies, 1992)

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Three common things can lead to decreased gut motility and therefore SIBO and SIFO: low progesterone levels , hypothyroidism, and low serotonin levels